p-Dichlorobenzene (106-46-7)
p-Dichlorobenzene is a halogenated hydrocarbon with CAS Registry Number 106-46-7. Under the OSHA air contaminants standard (29 CFR 1910.1000), its Permissible Exposure Limit (PEL) — the legal 8-hour time-weighted average (TWA) for general industry — is 75 ppm. The principal target organs are the Liver; kidneys; eyes, and workplace air is sampled and analyzed by NIOSH 1003.
Exposure Limits at a Glance
| Limit | Value | Basis |
|---|---|---|
| OSHA PEL (8-hr TWA) | 75 ppm | 29 CFR 1910.1000 |
| NIOSH REL | See note below | NIOSH Pocket Guide |
| Hazard Class | Halogenated Hydrocarbon | Halogenated |
| Target Organs | Liver; kidneys; eyes | NIOSH / OSHA |
| Sampling Method | NIOSH 1003 | NIOSH Manual of Analytical Methods |
NIOSH REL note: NIOSH recommends the lowest feasible concentration (LOQ-based) for many chlorinated solvents. The REL is a non-regulatory recommendation; where a NIOSH REL exists it is typically more protective than the OSHA PEL.
How It Enters the Body & Health Effects
Exposure to p-Dichlorobenzene is assessed against the Liver; kidneys; eyes — the organ systems most consistently affected in occupational studies. Employers must ensure no employee’s 8-hour TWA exceeds the 75 ppm PEL, and must use engineering controls, work practices, and — where required — respiratory protection to keep exposures at or below that level.
- Hazard class: Halogenated Hydrocarbon. Halogenated-class agents are managed with the hierarchy of controls (elimination, substitution, engineering controls, administrative controls, then PPE).
- Monitoring: collect personal air samples in the breathing zone and submit them under NIOSH 1003 for laboratory analysis.
- Medical surveillance: consult the OSHA substance-specific standards and the NIOSH Pocket Guide when the target organs are the Liver; kidneys; eyes.
Sampling & Compliance Notes
- Determine whether the exposure is a full-period 8-hour TWA or a short-term / ceiling scenario. Ceiling and STEL excursions apply to several Halogenated-class agents regardless of the 8-hour average.
- Calibrate personal sampling pumps before and after each shift and record flow rates; method NIOSH 1003 specifies media, flow, and analysis.
- Compare analytical results to the OSHA PEL of 75 ppm and the NIOSH REL. Document the higher of the two for internal exposure-control targets.
- Where the PEL includes a “skin” notation, dermal absorption can contribute to the dose — glove selection and hygiene facilities are part of compliance.
Frequently Asked Questions
What is the OSHA PEL for p-Dichlorobenzene?
The OSHA Permissible Exposure Limit (8-hour TWA) for p-Dichlorobenzene is 75 ppm.
What is the CAS number for p-Dichlorobenzene?
The CAS Registry Number for p-Dichlorobenzene is 106-46-7.
What are the target organs for p-Dichlorobenzene?
The primary target organs are the Liver; kidneys; eyes.
How do you measure p-Dichlorobenzene in workplace air?
Use NIOSH analytical method NIOSH 1003 for air sampling and laboratory analysis.
What hazard class is p-Dichlorobenzene?
It is classified here as a Halogenated Hydrocarbon (Halogenated).